The condition for the connection of the regional economies to global processes is the ability to improve its efficiency in using the resource of the region. Knowledge is now becoming a key resource and valuable ability is to manage it and co-operate with main institutions that produce it and promote its diffusion. Human capital of the region determines its success. Silesia is a region with the largest number of specialists with higher technical education in Europe. Concentration of industry and creating class of professionals make this traditional industrial region to become a learning region. Surveys conducted among the regional leaders and entrepreneurs confirm this.